The thyroid gland produces the protein thyroglobulin, which is a precursor to the thyroid hormones triiodothyronine (T3) and thyroxine (T4). It is produced and kept as a big glycoprotein in the thyroid gland’s follicular cells.

The synthesis of thyroglobulin is one of the phases in the process of making thyroid hormone. Within the colloid of thyroid follicles, thyroglobulin acts as a scaffold for the synthesis and storage of thyroid hormones. Thyroglobulin is metabolized and released into the bloodstream in conjunction with thyroid hormones when the thyroid gland is activated by thyroid-stimulating hormone (TSH).

In clinical practice, thyroglobulin levels are primarily assessed in patients who have had treatment for thyroid cancer as a tumor marker. Following a thyroidectomy, which is a surgical removal